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KMID : 0357920090430050441
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Korean Journal of Pathology
2009 Volume.43 No. 5 p.441 ~ p.447
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Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women
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Choi Ga-Won
Kim Kyu-Rae
Khang Shin-Kwang
Kim Jeong-Won
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Abstract
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Background: Despite an increased incidence of endometrial carcinomas in young Korean women, clinicopathologic characteristics and treatment outcomes have not been analyzed.
Methods: We investigated clinicopathologic characteristics of endometrial carcinoma in 48 women who were under the age of 40 in order to determine treatment guideline.
Results: According To The Criteria Of The Korean Society For Obesity, 70.8% Of Study Patients Were Overweight Or Obese, With An Average Body Mass Index (Bmi) Of 26.0 kg/m2. Twelve Patients Received Progesterone Treatment Only, And 6 Of Them Later Had Successful Pregnancies. The Histologic Subtype Was Endometrioid Adenocarcinoma In All Patients. Figo Stages Were 1a (41.7%), 1b (47.1%), Iia (2.8%), Iib (2.8%), Iiia (2.8%), And Iiic (2.8%). Figo Grades Were Grade 1 (79%) Or 2 (21%). The Average Depth Of Invasion, Excluding Stage 1a, Was 4.6 Mm In The Hysterectomy Specimens. Two Patients Were Given Post-operative Radiation Treatment And 4 Were Treated With Chemotherapy. All But One Case Had An Uneventful Postoperative Course During Follow-up.
Conclusions: A majority of endometrial carcinomas in young Korean women were associated with an early FIGO stage, favorable histologic subtype and grades, and a good prognosis. Progesterone treatment with close observation was a successful treatment option in a selected group of young patients.
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KEYWORD
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Carcinoma, Endometrium, Young age, Progesterone therapy, Pregnancy
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